5 Days Rome & Florence Itinerary

Embarking on a journey through the captivating cities of Rome and Florence is like stepping into a living history book. These two Italian gems are not just destinations; they’re immersive experiences that beg to be savored. As I recount my 5-day adventure, I can’t help but marvel at the rich tapestry of history woven into the cobblestone streets and ancient architecture.

I recommend not try to see everything and squeeze in Pompeii and the Amalfi Coast in these 6 days since there is just so much to see. Each corner tells a story, each monument whispers centuries-old secrets, and each alleyway is a portal to the past. So, buckle up for a leisurely ride through time as we explore the enchanting streets of Rome and Florence, where every moment deserves its own chapter.

Arriving in Rome

We arrived at Leonardo da Vinci–Fiumicino Airport (ROM). The Fiumicino Aeroporto train operates every 30 minutes and provides direct transportation to downtown Rome (Roma Termini). I suggest opting for trains instead of renting a car, as car rentals can be quite expensive in the city of Rome, and parking costs are even higher.

Traveling with Kids

Traveling with a toddler, we found Rome to be a wonderfully walkable city. To make exploring easier, we decided to rent a stroller from Babonbo, which connects you with local families offering rentals. The process was simple: I signed up, chose the stroller I wanted, and made the upfront payment. The renters reached out to me through WhatsApp, requesting flight details and arranging a convenient pickup location. Their flexibility and helpfulness extended beyond just the stroller— they provided great recommendations for hotels and restaurants. I highly recommend Babonbo for a seamless and supportive experience.

Day 1: Spanish Steps, Trevi Fountain, Pantheon, Piazza Navona, Campo De ‘Fiori

Breakfast: At the hotel

Lunch: Pinsitaly Trevi really good food. They make it all with fresh ingredients.

Dinner: We just ate at a local shop, grabbed a pizza slice. You can’t go wrong with Italian food anywhere in Italy.

These are the highlights for day 1 but you go anywhere else, you will just love the beauty and history at every corner.

Day 2: Vatican City, Castel Sant’Angelo, Trastevere

On the third day, take a day trip to the smallest country in the world—the Vatican City.

Embark on your Vatican Museums adventure early, encompassing a vast array of 26 museums housing an extensive collection of artifacts. Appreciating every piece could take days or weeks, but with only one day, we recommend opting for a guided Vatican Museum Tour to witness the key highlights. Dive into the awe-inspiring Sistine Chapel, home to two of the world’s greatest masterpieces—Michelangelo’s ceiling frescoes and his Giudizio Universale (Last Judgment).

Following this, venture to St. Peter’s Basilica, a monumental work of art and one of the world’s largest churches. Don’t miss the opportunity to ascend the lofty dome; the panoramic view from there is truly spectacular.

Upon departing St. Peter’s Square, take a stroll down Via della Concilliazione, leading you to Castel Sant’Angelo. Situated along the banks of the River Tiber, this ancient edifice is among the oldest in Rome, boasting a captivating history as a fortress, castle, and now a museum. The rooftop terrace affords one of the finest panoramic views of the city.

Conclude your day with a delightful dinner in Trastevere, a vibrant district filled with restaurants and lively nightlife. We ate at Tonnarello and I will go there again. The vibe and food was outstanding.

Day 3: The Colosseum, Roman Forum, Palatine Hill, Monti, Piazza Venezia, Campidoglio

Kick off your Rome adventure by visiting the Colosseum, the ultimate symbol of the city. This massive amphitheater has stood tall for over 2,000 years, hosting up to 80,000 spectators cheering on their favorite gladiators. Pro tip: Grab a skip-the-line ticket to dodge the scorching heat and get the lowdown from your guide.

The ticket not only gets you into the Colosseum but also grants access to the nearby Roman Forum and Palatine Hill. After checking out the arena and giving props to the Arch of Constantine, swing by the Roman Forum—it complements the Colosseum like peanut butter and jelly. If you’re DIY-ing the Colosseum, consider a guided tour of the Roman Forum for some epic history lessons. Wrap up your morning by climbing Palatine Hill for killer views of the ruins.

Work up an appetite? Head to the charming Monti district for lunch—a historic neighborhood with a cool vibe, boutique stalls, and top-notch bars and restaurants. Don’t skip the Basilica di Santa Maria Maggiore and the Basilica di Santa Prassede.

Come late afternoon, hit up Piazza Venezia and take in the Altar of the Fatherland, a massive monument that’s hard to ignore. The Vittoriano offers jaw-dropping views of Rome (first two terraces are free, but the third comes with a fee). Hop on the glass elevator to the top for one of Rome’s best views. Right next to Vittoriano is Capitoline Hill, also serving up stunning city views. Explore the Piazza del Campidoglio, a unique square designed by Michelangelo. Alternatively, roll with a guided tour to hit up all the hotspots in the area.

Day 4: Train to Florence, Duomo, Mercado Centrale, Uffizi Gallery, Ponte Vecchio, Pitti Palace & Gelato

Begin your day by exploring the iconic Florence Cathedral, including the Baptistery and Giotto’s Campanile. Consider climbing to the top of the dome for panoramic views.

Head to the Accademia Gallery to marvel at Michelangelo’s David and other Renaissance masterpieces. Enjoy a delicious lunch at Mercato Centrale, a vibrant indoor market with various food stalls offering local delights. Spend the afternoon at the Uffizi Gallery, home to an extensive collection of Renaissance art. Book tickets in advance to skip the lines.

Take a stroll along the Ponte Vecchio and visit the Pitti Palace and Boboli Gardens and eat a Gelato.

Day 5: Palazzo Vecchio, Piazza della Signoria & Shopping


Start your day with a tour of Palazzo Vecchio. Explore the historical chambers, admire Renaissance artworks, and climb the tower for panoramic views of Florence. Stroll to Piazza della Signoria, the heart of Florence. Marvel at the outdoor sculpture gallery, including the Fountain of Neptune and the impressive replica of Michelangelo’s David.

Enjoy a leisurely lunch in one of the charming trattorias around Piazza della Signoria. Indulge in Tuscan specialties and soak in the lively atmosphere.

Head to Via de’ Tornabuoni, Florence’s high-end shopping street. Explore luxury boutiques and iconic Italian fashion brands. Don’t miss the chance to shop for leather goods in Florence. Walk towards Ponte Vecchio, the famous medieval bridge lined with jewelry shops. Admire the Arno River and capture some memorable photos.

Venture into the nearby markets such as Mercato del Porcellino or Mercato di San Lorenzo for unique souvenirs, local crafts, and more. Conclude your day with a gelato from a local gelateria and head to Piazzale Michelangelo for breathtaking views of Florence at sunset.

As your memorable 5-day journey through Rome and Florence comes to an end, reflect on the rich history, art, and culinary delights you’ve experienced. From the awe-inspiring Colosseum in Rome to the artistic treasures of Florence, each day has been filled with discoveries and cultural immersion. As you bid farewell to these enchanting cities, carry with you the echoes of ancient civilizations, the vibrancy of Renaissance masterpieces, and the flavors of authentic Italian cuisine. Whether you explored the iconic landmarks or wandered through charming neighborhoods, this dual-city adventure has undoubtedly left an indelible mark on your travel memories. Until your next Italian escapade, arrivederci!

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